Good News on Psilocybin for Major Depression

Scientific research on cptsd

Not that anyone following me on Twitter will be surprised to hear this – but – in case you haven’t, there is research coming out of Johns Hopkins Medicine that is good news for sufferers of major depression.

From the article –

The findings of a small study of adults with major depression, published Nov. 4, 2020, in JAMA Psychiatry, suggest that psilocybin may prove effective in a larger population of patients with intractable depression than previously appreciated.

This is great news. Do remember that it is only a very small study. Only 24 participants. But, the findings mean that there could be more trials and greater acceptance (and knowledge) of using psilocybin to treat major depression.

Griffiths and his colleagues reported that two doses of psilocybin during medically supervised treatment — supplemented by supportive psychotherapy — produced rapid and large reductions in depressive symptoms.

Milestone Study Shows Psychedelic Treatment with Psilocybin Relieves Major Depression

Tragedy

My Brother

My brother
A name
I simply moved
From
One column
To another.

Another Day

The fight to live

Another day
Another ten rounds
Even when you can’t
You don’t want
To fight.

Any more.

No mas. No mas.

Those are the days
To fight the hardest.

We fight to live.

New class of antidepressants?

Scientific research on cptsd

Source C&E News February 7, 2022

How do you know if a mouse is hallucinating?

Apparently mice on LSD and psilocybin twich their heads. Fascinating. But then, if I was a mouse and my world had gone all psychotropic I suspect there would be some head twitching, too.

So what do tripping mice have to do with Complex PTSD?

As many readers may already know LSD and psilocybin are two controlled substances that have been demonstraated to help alleviate mood disorders. In light of CPTSD these mood disorders may include depression, major depression, persistent depression and psychotic depression. (yes, we are such a fun bunch. </sarcasm>)

Why do these drugs help with Complex PTSD?

The simple answer is ‘brain chemistry’.

The longer answer goes like this:
There is a receptor in the central nervous system called 5-HT2A. This receptor is where serotonin binds to the cell. Serotonin in the brain is linked with mood, anxiety regulation, sexuality, memory, and some social fascets. In essence, your brain is bathing in serotonin. This is why SSRI – Selective Serotonin Reuptake Inhibitors – class drugs are often prescribed to people with symptoms of depression.
Simple logic – raise the level of serotonin in the brain –> lower the presence of depression symptoms.

Guess what else binds to 5-HT2A. If you said magic mushrooms (psilocybin) and LSD you are correct.

However, these drugs also induce hallucinations. Psilocybin is “a Schedule I controlled substance because it has no approved medical purpose and the potential for abuse.”** LSD is also a Schedule I controlled substance. ***

What scientists are trying to discover is – what is the difference between a compound that binds to 5-HT2A that causes hallucinations vs. one that does not. That discovery will open an area of research into new antidepressive medication. It could also prove valuable for people who need antipsychotic medication.

So far scientists have produced two compounds based on this research that demonstrate antidepressant activity without hallucinations in mice.

There is a long step between the lab and a safe effective human medication. The process can take years. But, there is hope, and growing proof, of a new way to help people who suffer from a chronic imbalance of brain chemistry.


Article is at : Hallucinogen Chemistry Guies Antidepressant Drug Discovery by Bethany Halford
[ https://pubs.acs.org/doi/pdf/10.1021/cen-10005-leadcon ] (Sorry, you need ACS membership.)

**(source: USDA [ https://www.usada.org/spirit-of-sport/magic-mushrooms-prohibited-status/ ] as of Feb. 16, 2022)
***(source: DEA [https://www.dea.gov/drug-information/drug-scheduling] as of Feb 16, 2022)

Counterpoint

Poetry Counterpoint Complex PTSD

Between the idea
And the reality
Between the motion
And the act
Falls the shadow
~TS Eliot
(The Hollow Men)

That space between
A point
Of precarious balance
Where we exist
Both alive and not.
~ M.Stewart
(on complex-ptsd)

Falling off the edge

a grayscale photo of medication pills

I don’t know if this post will go up. Really. 
Most of my posts are crafted in a place of cerebral analytic detachment. This post originates in intense visceral pain. 
Still sounds like it is running through the brain, doesn’t it? Well, I have to do that, or I wouldn’t be able to spell viscera. 
Focus. 

Pain. Terror. The only way I could sum this up to myself or to anyone else is simply, I hurt. 
It doesn’t help that I’m quartering my meds. The Dr., the Pharmacy, the Insurance company are all looking at one another and telling me that I am not their problem. 

Meanwhile – I’m running out of my medication. 

I spoke to the state oversight board of insurers. Well, sure I can file a complaint – and then wait 30 days. 

30 days. 
Right. 
Did I mention one of the risks of rapid ungoverned withdrawal is psychosis? 

I’ve already been fighting for nearly 30 days, to get my medication. To keep some semblance of control over my emotions and my mind. 

I’m quartering my dose just to try to keep total implosion from happening. 

I feel like I’m losing. 
I feel like I’m being torn apart. 
I feel frightened. 
I feel – too much. 

What is Complex-PTSD (CPTSD)

Complex PTSD - balance

Definition of CPTSD


Complex post traumatic stress disorder
is a psychological disorder that can develop in response to prolonged, repeated experience of trauma in a context where the individual has little or no chance of escape.

Honestly, I can’t remember if these are my words or not. Please tell me if they are yours.

That is the clinical definition of Complex-PTSD (CPTSD). Other resources will explain CPTSD as a form of PTSD that has other overlying factors. The two can be easily confused if you don’t start with the definition. The definition above holds some key phrases.

The first is “prolonged, repeated experience of trauma.” Most instances of PTSD are traced back to a single horrific event. Not so with CPTSD. Someone who has this form of mental wound has experienced not one instance of trauma, but multiple instances, even possibly their entire life.

The second phrase to take note of is “little or no chance to escape”. I would add the words ‘over time’ to that phrase, because that is a key part of CPTSD. Anyone who has suffered trauma was not in a situation to escape – but where PTSD is an instance, CPTSD plays out over a long period of time. The person who is being traumatized has no means to escape their situation.

Persistent feelings of worthlessness or emptiness are a sign of CPTSD.
constant feelings of emptiness or hopelessness

There is another central issue when differentiating PTSD from CPTSD and that is the mind that experiences the trauma. The initial group of the population where PTSD was observed was military veterans. In this group, the men and women were all over 18 years of age when they experienced trauma. This is important because most of their cerebral development was done. They knew who they were, and they knew who they wanted to return to being after the trauma.

When we talk about CPTSD the trauma can start as early as infancy. That is perhaps the most important difference. In PTSD the individual, usually an adult, has a point before the trauma to return to. People with CPTSD have no previous to return to in many cases because they were shaped from their earliest moments by their traumatic environment.

Symptoms of PTSD and CPTSD

Complex PTSD builds on the already accepted symptoms associated with PTSD. So, while someone with PTSD will experience symptoms from the list on the left, someone with CPTSD will experience symptoms from both lists.

PTSD

  • Memories of the trauma.
  • Flashbacks – Reliving the trauma.
  • Dreams or nightmares
  • Emotional or physical reactions to reminders
  • Trying to avoid thinking or talking about the event
  • Avoiding anything that reminds you of the event.
    Negative thoughts about damn near everything.
  • Hopelessness about the future
  • Memory problems
  • Difficulty maintaining close relationships
  • Feeling detached from family and friends
  • Depression
  • Feeling emotionally numb
    Being easily startled or frightened
  • Always being on alert
  • Self-destructive behavior
  • Trouble sleeping
  • Trouble concentrating
  • Irritability, angry outbursts or aggressive behavior
  • Overwhelming guilt or shame

CPTSD

  • difficulty controlling your emotions
  • feeling very angry or distrustful towards the world
  • constant feelings of emptiness or hopelessness
  • feeling as if you are permanently damaged or worthless
  • feeling as if you are completely different to other people
  • feeling like nobody can understand what happened
  • avoiding friendships and relationships, or finding them very difficult

dissociative symptoms 
depersonalisation or derealisation

physical symptoms: headaches, dizziness, chest pains and stomach aches

regular suicidal feelings.

This list is from mind.org.uk

Emotional Flashbacks vs. Flashbacks

You would think that there wouldn’t be a dividing line between these two terms. After all, both are moments when the brain is hijacked by the past and trauma is reexperienced. The difference lies in the brain. A flashback is a full sensory being there re-experiencing of the trauma. The person can see, feel, even smell and taste all the details of the event. Those details are stored in their memory. They reexperience every part of that trauma.

The concept of the emotional flashback extends this to include periods of early childhood where the ability of the brain to form, store and retrieve memories is still developing. Particularly in the area of the visual cortex. What that means is that the memories of the event are stored complete with all the associated emotions, but there is no visual context. So when you encounter something that triggers a memory of that trauma – you are instantly swept back to the emotions of that time. And, you have nothing to correlate it with.

This being flung into emotions that are overpowering, without knowing why, or being able to point to any specific memory is one of the most disorienting, and in my opinion frightening aspects of CPTSD.

Core Beliefs of CPTSD

If you would like to see more memes to help share information on CPTSD please visit the Meme collections.

The manner in which the other major symptoms of CPTSD can manifest are as varied as the people who suffer with this condition. One core belief that many people with CPTSD have is that they are essentially fatally flawed. And because of their own brokenness, they are undeserving – of anything.

This is the core belief that tells us we are not worth ‘the bother’. This is the core belief that makes us accept the least. This is the core belief that makes it difficult, at the least, to face conflict. The script in our head says we are not worthy of our parents love, therefore we are not worthy. It is the core belief that we are worthless, completely without value.

CPTSD: Survival before growth

Most of the people with CPTSD have created defenses to keep them safe from their early environments. Most of the people who live with CPTSD are fiercely independent. We are also likely to be stoic. But many of these traits come from the need as a young child to be ‘easy’. Many people report a similar scenario of not asking for anything, because asking was dangerous. Others report that they abandoned things they enjoyed for the sake of peace. Many of the strategies we developed as children were not to explore our world, but instead to survive our world.

Where are we now

Post Traumatic Stress Disorder (PTSD) is more widely known in the public. Efforts to educate about this mental wound, typically found in soldiers but also victims of violence, have been ongoing since the 1980s. In contrast the study of CPTSD is relatively new. So new, that it is not yet included in the American Psychiatric Association’s Diagnostic and Statistical Manual of Mental Disorders (DSM-5)

But, European sources are starting to recognize that CPTSD is a disorder that should be recognized as a unique set of symptoms, behaviors and challenges. Hopefully, one day the DSM will follow.

There is a great deal more to convey but, for now, to sum it all up, Complex-PTSD is a bitch. Really.

Coming Alive Amidst a Pandemic.

Gabby Petito

Oh, the irony.
Thirty plus years of
Being various degrees of suicidal
And now we have a pandemic
Upending the world
I want to live.

Strangely, that’s about average for me.
Let me take a moment to unpack this one.

My depression started somewhere in seventh or eighth grade.
It’s possible it started earlier, but
I have no memories earlier
Except for a very few, so let’s say – around 12.

At age 12 I started to self-harm.
‘Escape’ was the word always in my thoughts.
I didn’t know much as a pre-teen
but, trust me, I knew I wanted out.

At this tender age
Out was still a fantasy
Of rescue or of running away.

Other people, with other issues,
Might have managed to escape on their own.
I couldn’t.

Where would I escape to?
Was escape even possible?
Did I even deserve better?
Who did I think I was?
This was where God put me.
This was my lot.
Suck it up.
Manage.

As a teenager, my resources changed.
I had access to a car and endless mountain roads.
I was always safe in my car.
I felt ‘in control’ of something.
That was where I started to think
Maybe, at least, I could control my death.

My fantasies of escape became fantasies of dying.
I wore black constantly.
I was erasing myself from my life.
(Not that there was much to erase.)
Vanishing before my own eyes.
I was content with that.

I was content with
The process of unbecoming
Because I had a way out.
Sitting in the driveway was
A 1980s bright orange mustang.
Ugly as sin, but the straight six was a beast.

Having that door made staying easier.
Because I knew I didn’t have to stay.
I had a choice.
Of all the things in my life that were broken,
Out of my control,
Dangerous, or terrifying.
I had control over one thing.
One choice.

How does all of this relate to today?
For better than 30 years
I managed to face tomorrow
Because I knew that if I didn’t want to,
If it was too hard, I didn’t have to.
I could stop.

In my 20s,
I saw all my friends growing and flying,
Becoming these spectacular people.
While I was sheathed in lead.
The learned helplessness,
The ‘shoulds’ of my family
Ruled every aspect of my life.

I slept a lot.
hoping I wouldn’t wake.
And when I was awake
I prayed to die.

Dear God,
Fix me.
Or finish me.

I actively debated suicide.
And came close to death a couple of times.

I was so depressed
I had my first hallucination.
Thankfully, it was also my last.

My 30s were calmer,
At least, on the surface.
I finally found help for the depression,
But not for the problem at the root of all of it.
Ideation moved back and forth
Between passive and active.

As my 30s wore on
I found the pendulum
Spent more time towards the passive side.
That was good.
I was able to function.

Although I went through the motions
I did not understand
This ‘joi de vivre’ that others expected

I’m not saying I was never happy.
I am saying every day was a trudge.
An exercise in existing.

So, where I slept through most of my 20s,
My 40s were marked by
A type of emotional numbness.
On occasion, the ice beneath my feet would break.
Plunging me into terror.

Two years ago,
Perhaps three
I finally made the connection with cptsd
I found a good therapist to work through it.
I’m still working on it.
Likely, I will for the rest of my life.

Now, I’m over 50 and discovering how to live.
I grieve so much of the life I missed.

So here’s the irony:
I’m writing. I adore my husband.
Finally, I am discovering who I am.
I have put most of my desire for death aside.
I want to live. I have something to live for.

Here, at a very scary moment,
In a world that I have always shunned
Because of my twisted roots,
At the moment when
Life seems most precarious,
My life is most precious.
Now – I want to live.

No, I’m not Procrastinating

Or maybe I am. This is a common saying around my desk. It’s a riff on Hemingway’s famous quote

Write drunk, edit sober.

E. Hemingway

Midnight Writing Jan 9, 2016

Some people travel through the Shadowlands and after trial and tribulation they emerge. They shake off the dark soot of so many sorrows and return to the sun.

I did not travel through. I lived in the Shadowlands. I ate of the fruit and drank from bitter streams. Years have passed here and the Shadowlands have swallowed decades. Now even though I, at times, emerge into the whiteness of the midday sun, I know that the Shadow is with me, hidden beneath my heel.  For I have learned, after long and ardent denial, that the Shadows live within me.